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Leuk Lymphoma. 2001 Aug;42(4):797-9.

2'-Deoxycoformycin for hepatosplenic gammadelta T-cell lymphoma.

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  • Department of Clinical Haematology and Medical Oncology, The Royal Melbourne Hospital, Parkville, Victoria, Australia. andrew.grigg@mh.org.au


We describe a patient with unusually indolent hepatosplenic gammadelta T cell lymphoma characterised by severe lassitude and high fever. No significant responses were obtained to a range of chemotherapeutic and biological agents. 2'-deoxycoformycin (dCF), however, produced a dramatic and sustained clinical and histological response. This is the second recent report of gammadelta T cell lymphoma responding to dCF, suggesting this agent may have a specific role in this condition.

[PubMed - indexed for MEDLINE]
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