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    J Ethnopharmacol. 2001 Dec;78(2-3):139-43.

    Effect of Ocimum sanctum fixed oil on blood pressure, blood clotting time and pentobarbitone-induced sleeping time.

    Singh S, Rehan HM, Majumdar DK.

    Source

    College of Pharmacy, University of Delhi, Pushp Vihar, 110017, New Delhi, India.

    Abstract

    Ocimum sanctum fixed oil produced hypotensive effect in anaesthetised dog, which seems to be due to its peripheral vasodilatory action. The oil increased blood-clotting time and percentage increase was comparable to aspirin and could be due to inhibition of platelet aggregation. The oil also increased pentobarbitone-induced sleeping time in rats indicating probable inhibitory effect of oil towards cytochromic enzyme responsible for hepatic metabolism of pentobarbitone.

    PMID:
    11694358
    [PubMed - indexed for MEDLINE]

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