Noble 2-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-iso...[Arch Pharm Res. 2001]

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1: Arch Pharm Res. 2001 Oct;24(5):367-70.Links

Noble 2-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-isoindolinone derivatives. part I: synthesis and SAR studies for the inhibition of TNF-alpha production.

Park JS, Baik KU, Cho JY, Yoo ES, Byun YS, Park MH.

Institute of Biosciences & Biotechnology, Daewoong Pharm Co. Ltd., Yongin, Kyunggi-do 449-814, Korea. joonchem@daewoong.co.kr

This study describes the synthesis and in vitro evaluation of noble 2-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-isoindolinone derivatives for the inhibition of TNF-alpha production. Among these compounds, 2-[3-(cyclopentyloxy)-4-methoxyphenyll-3-methyl-1-isoindolinone (5) was the most potent in inhibitory activity of TNF-alpha production in LPS-stimulated RAW264.7 cells.

PMID: 11693533 [PubMed - indexed for MEDLINE]

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Noble 2-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-isoindolinone derivatives. part I: synthesis and SAR studies for the inhibition of TNF-alpha production.

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