Send to:

Choose Destination
See comment in PubMed Commons below
J Allergy Clin Immunol. 2001 Nov;108(5):871-3.

Epinephrine absorption in adults: intramuscular versus subcutaneous injection.

Author information

  • 1Section of Allergy & Clinical Immunology, Department of Pediatrics & Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.


We report a prospective, randomized, blinded, placebo-controlled, 6-way crossover study of intramuscular versus subcutaneous injection of epinephrine in young men. Peak plasma epinephrine concentrations were significantly higher (P < .01) after epinephrine was injected intramuscularly into the thigh than after epinephrine was injected intramuscularly or subcutaneously into the upper arm. We recommend intramuscular injection of epinephrine into the thigh as the preferred route and site of injection of this life-saving medication in the initial treatment of anaphylaxis.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk