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Am J Psychiatry. 2001 Nov;158(11):1920-2.

Neural correlates of traumatic memories in posttraumatic stress disorder: a functional MRI investigation.

Author information

  • 1Department of Psychiatry, University of Western Ontario, London, Canada. ruth.lanius@lhsc.on.ca

Abstract

OBJECTIVE:

The neuronal circuitry underlying posttraumatic stress disorder (PTSD) was studied in traumatized subjects with and without PTSD.

METHOD:

Traumatized subjects with (N=9) and without (N=9) PTSD were studied by using the script-driven symptom provocation paradigm adapted to functional magnetic resonance imaging at a 4-T field strength.

RESULTS:

PTSD subjects showed significantly less activation of the thalamus, the anterior cingulate gyrus (Brodmann's area 32), and the medial frontal gyrus (Brodmann's area 10/11) than did the comparison subjects.

CONCLUSIONS:

The findings suggest anterior cingulate, frontal, and thalamic involvement in the neuronal circuitry underlying PTSD.

PMID:
11691703
[PubMed - indexed for MEDLINE]
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