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Am J Psychiatry. 2001 Nov;158(11):1911-3.

Enhancing comprehension of consent for research in older patients with psychosis: a randomized study of a novel consent procedure.

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  • 1Department of Psychiatry, University of California, San Diego, USA.



The ability of individuals with schizophrenia to provide informed consent for research has become the focus of public debate. The authors examined whether a novel consent procedure improved the comprehension of consent for older patients with psychosis.


Fifty outpatients with schizophrenia or other psychotic disorders and 19 normal comparison subjects aged 40-80 were randomly assigned to groups given either a routine or an enhanced consent procedure. The latter utilized a computerized presentation that included sequential bullet points and summaries of key information. A posttest measured comprehension of consent-relevant information.


A significantly greater proportion of patients who received the enhanced consent procedure scored 100% on first and second trials of the posttest, compared to those receiving the routine procedure (trial 1: 42.3% versus 8.3%; trial 2: 80.8% versus 45.8%, respectively).


The enhanced consent method improved comprehension of information relevant for consent in older patients with psychosis.

[PubMed - indexed for MEDLINE]
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