Your browser version may not work well with NCBI's Web applications. More information here...
1: Biochem Biophys Res Commun. 2001 Nov 9;288(4):786-8.Click here to read Links

CD147 is a signaling receptor for cyclophilin B.

Yurchenko V, O'Connor M, Dai WW, Guo H, Toole B, Sherry B, Bukrinsky M.

The Picower Institute for Medical Research, Manhasset, New York 11030, USA.

Cyclophilins A and B (CyPA and CyPB) are cyclosporin A binding proteins that can be secreted in response to inflammatory stimuli. We recently identified CD147 as a cell-surface receptor for CyPA and demonstrated that CD147 is an essential component in the CyPA-initiated signaling cascade that culminates in ERK activation and chemotaxis. Here we demonstrate that CD147 also serves as a receptor for CyPB. CyPB induced Ca(2+) flux and chemotaxis of CD147-transfected, but not control, CHO cells, and the chemotactic response of primary human neutrophils to CyPB was blocked by antibodies to CD147. These results suggest that CD147 serves as a receptor for extracellular cyclophilins. Copyright 2001 Academic Press.

PMID: 11688976 [PubMed - indexed for MEDLINE]