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Mol Cell. 2001 Oct;8(4):732-3.

New twists in understanding the fate of antisense oligodeoxynucleotide mRNA targets.

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  • 1Howard Hughes Medical Institute, University of Arizona, Tucson, AZ 85721, USA.


In this issue of Molecular Cell, Thoma et al. show that after a target mRNA is cleaved, upon treatment with an antisense oligodeoxynucleotide, the 3' cleavage product persists and is translated to produce an N-terminally truncated version of the protein encoded by the target mRNA.

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