Format

Send to:

Choose Destination
See comment in PubMed Commons below
Neuropsychopharmacology. 2001 Nov;25(5 Suppl):S68-73.

The effects of total sleep deprivation on cerebral responses to cognitive performance.

Author information

  • 1Department of Psychiatry, University of California, San Diego and San Diego Veterans Affairs Medical Center, San Diego, CA 92161, USA. drummond@ucsd.edu

Abstract

We review the findings from a study utilizing functional magnetic resonance imaging (FMRI) to examine the effects of total sleep deprivation (TSD) on verbal learning, arithmetic, and divided attention. For verbal learning and divided attention, TSD was associated with increased activation in the bilateral prefrontal cortex and parietal lobes. Increased sleepiness after TSD and lower levels of memory impairment were correlated with increased activation in specific regions of the prefrontal cortex and parietal lobes, respectively. The arithmetic task led to significantly decreased activation in the bilateral prefrontal cortex and parietal lobes. Based on this and other data, we hypothesize an adaptive cerebral response during cognitive performance following TSD with the specific pattern of adaptation depending on the specific cognitive processes performed. We discuss the need to test the hypothesis in a variety of ways.

PMID:
11682277
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk