Send to

Choose Destination
See comment in PubMed Commons below
J Antimicrob Chemother. 2001 Nov;48(5):597-603.

Use of antibiotic locks to treat colonized central venous catheters.

Author information

  • 1Department of Medical Microbiology, Freeman Hospital, Newcastle upon Tyne NE7 7DN, UK.


Infections that result from bacterial colonization of central venous catheters are a significant problem in modern healthcare. The most effective means of eradication of such infections is the removal of colonized lines, but line removal carries drawbacks of its own and in many cases the balance of risks favours treatment in situ. Systemic antibiotics are usually administered but these frequently fail to achieve sterilization, and accordingly attention has turned to intraluminal therapy using antibiotic locks, in which 1-2 mL of a concentrated antibiotic solution is instilled to fill the lumen, left for a predetermined period, and removed. The evidence in favour of this technique is anecdotal and should not be allowed to influence any decision about line removal, but is sufficiently encouraging to justify the use of locks when in situ treatment is deemed acceptable. Indications, agents and appropriate administration regimes are discussed.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk