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Morphogen gradient interpretation.
Wellcome/CRC Institute, Cambridge, UK. j.gurdon@welc.cam.ac.uk
A morphogen gradient is an important concept in developmental biology, because it describes a mechanism by which the emission of a signal from one part of an embryo can determine the location, differentiation and fate of many surrounding cells. The value of this idea has been clear for over half a century, but only recently have experimental systems and methods of analysis progressed to the point where we begin to understand how a cell can sense and respond to tiny changes in minute concentrations of extracellular signalling factors.
PMID: 11677596 [PubMed - indexed for MEDLINE]
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Cited by 36 PubMed Central articles
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Plausibility of stromal initiation of epithelial cancers without a mutation in the epithelium: a computer simulation of morphostats.
Baker SG, Soto AM, Sonnenschein C, Cappuccio A, Potter JD, Kramer BS.
BMC Cancer. 2009 Mar 23; 9:89. Epub 2009 Mar 23.
[BMC Cancer. 2009]
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Neutrality and robustness in evo-devo: emergence of lateral inhibition.
Munteanu A, Solé RV.
PLoS Comput Biol. 2008 Nov; 4(11):e1000226. Epub 2008 Nov 21.
[PLoS Comput Biol. 2008]
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Conversion of the nipple to hair-bearing epithelia by lowering bone morphogenetic protein pathway activity at the dermal-epidermal interface.
Mayer JA, Foley J, De La Cruz D, Chuong CM, Widelitz R.
Am J Pathol. 2008 Nov; 173(5):1339-48. Epub 2008 Oct 2.
[Am J Pathol. 2008]
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