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Curr Biol. 2001 Oct 16;11(20):R842-4.

DNA replication: partners in the Okazaki two-step.

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  • Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King's Buildings, EH9 3JR, Edinburgh, UK. s.a.macneill@ed.ac.uk


The correct processing of Okazaki fragments during lagging-strand DNA replication has a vital role in maintaining genome integrity. Recent findings suggest that, in eukaryotes, the processing of Okazaki fragments occurs by a two-step mechanism governed by the single-stranded DNA binding factor RPA.

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