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Neurology. 2001 Oct 23;57(8):1515-7.

Controlled trial of N-acetylcysteine for patients with probable Alzheimer's disease.

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  • 1Neurology Service, Albuquerque Veterans Affairs Medical Center, New Mexico, USA.


The antioxidant N-acetylcysteine (NAC) or placebo was administered in a double-blind fashion to patients who met National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria for probable AD. Testing for efficacy occurred after 3 and 6 months of treatment. Comparison of interval change favored NAC treatment on nearly every outcome measure, although significant differences were obtained only for a subset of cognitive tasks.

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