Science. 1975 Oct 31;190(4213):488-9.

Time-dependent effects of phenothiazines on dopamine turnover in psychiatric patients.

Abstract

Psychiatric patients studied early during treatment with chlorpromazine and thioridazine demonstrated elevated probenecid-induced accumulations of homovanillic acid, a major dopamine metabolite, in cerebrospinal fluid. In those studied after longer periods of treatment with phenothiazines, homovanillic acid values were not elevated. This suggests that there are time-dependent effects of phenothiazines on dopamine turn-over that may be relevant to the time course of antipsychotic efficacy.

PMID:: 1166321; [PubMed - indexed for MEDLINE]

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Thioridazine: central dopamine turnover and clinical effects of antipsychotic drugs. [Clin Pharmacol Ther. 1975]
Thioridazine: central dopamine turnover and clinical effects of antipsychotic drugs.
Bowers MB Jr. Clin Pharmacol Ther. 1975 Jan; 17(1):73-8.
Mass fragmentometric determination of homovanillic acid in lumbar cerebrospinal fluid of schizophrenic patients during treatment with antipsychotic drugs. [J Psychiatr Res. 1974]
Mass fragmentometric determination of homovanillic acid in lumbar cerebrospinal fluid of schizophrenic patients during treatment with antipsychotic drugs.
Sedvall G, Fyrö B, Nybäck H, Wiesel FA, Wode-Helgodt B. J Psychiatr Res. 1974; 11:75-80.
Effect of drugs used in psychoses on cerebral dopamine metabolism. [Br J Pharmacol. 1970]
Effect of drugs used in psychoses on cerebral dopamine metabolism.
O'Keeffe R, Sharman DF, Vogt M. Br J Pharmacol. 1970 Feb; 38(2):287-304.
Review Perspectives on a time-dependent model of neuroleptic action. [Schizophr Bull. 1988]
Review Perspectives on a time-dependent model of neuroleptic action.
Pickar D. Schizophr Bull. 1988; 14(2):255-68.
Review Cerebrospinal fluid probenecid studies: a reinterpretation. [Biol Psychiatry. 1983]
Review Cerebrospinal fluid probenecid studies: a reinterpretation.
Cowdry RW, Ebert MH, van Kammen DP, Post RM, Goodwin FK. Biol Psychiatry. 1983 Nov; 18(11):1287-99.

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Cited by 1 PubMed Central article

The effect of propranolol on CSF amine metabolites in psychiatric patients. [Br J Clin Pharmacol. 1983]
The effect of propranolol on CSF amine metabolites in psychiatric patients.
King DJ, Cooper SJ, Liddle J. Br J Clin Pharmacol. 1983 Mar; 15(3):331-7.

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