Oncogene. 2001 Oct 1;20(44):6273-83.

The transmembrane adapter LAT plays a central role in immune receptor signalling.

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Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK. peter.wonerow@phsrm.ox.ac.uk

Abstract

The transmembrane adapter LAT (linker for activation of T cells) plays a central role in signalling by ITAM bearing receptors expressed on T cells, natural killer cells, mast cells and platelets. Receptor engagement leads to the phosphorylation of tyrosine residues present in the intracellular domain of LAT and formation of a multiprotein complex with other adapter molecules and enzymes including Grb2, Gads/SLP-76 and PLCgamma isoforms. These signalling events predominantly take place in glycolipid-enriched membrane domains. The constitutive presence of LAT in GEMs enables its function as the main scaffolding protein for the organization of GEM-localized signalling. The study of LAT-deficient mice and LAT-deficient cell lines further emphasizes the importance of LAT for these signalling cascades but also defines the existence of LAT-independent events downstream of the Syk-family kinase-ITAM complex.

PMID:: 11607829; [PubMed - indexed for MEDLINE]

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The transmembrane adapter LAT plays a central role in immune receptor signalling.

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