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J Am Acad Dermatol. 2001 Nov;45(5):S176-82.

Isotretinoin effects on bone.

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  • 1Division of Dermatopharmacology, Department of Dermatology, Brown University School of Medicine/Rhode Island Hospital, 593 Eddy St., Providence, RI 02903, USA.


Isotretinoin has demonstrated efficacy in a wide range of disorders. The beneficial effects of the drug, however, are limited by its adverse effects on the bone. Children exposed to high doses are at risk for premature epiphyseal closure, while adults on long-term therapy have an increased tendency to develop hyperstosis and other changes of the bone. The knowledge of these effects, in conjunction with continued surveillance, are necessary for expert management and can ensure many years of efficacious treatment with minimal toxicity.

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