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Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12409-13. Epub 2001 Oct 16.

Deamidation of human proteins.

Author information

  • 1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA. noahr@its.caltech.edu

Abstract

Deamidation of asparaginyl and glutaminyl residues causes time-dependent changes in charge and conformation of peptides and proteins. Quantitative and experimentally verified predictive calculations of the deamidation rates of 1,371 asparaginyl residues in a representative collection of 126 human proteins have been performed. These rates suggest that deamidation is a biologically relevant phenomenon in a remarkably large percentage of human proteins.

PMID:
11606750
[PubMed - indexed for MEDLINE]
PMCID:
PMC60067
Free PMC Article
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