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J Virol. 2001 Nov;75(22):11218-21.

Human cytomegalovirus open reading frame TRL11/IRL11 encodes an immunoglobulin G Fc-binding protein.

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  • 1Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

Several herpesviruses encode Fc receptors that may play a role in preventing antibody-mediated clearance of the virus in vivo. Human cytomegalovirus (HCMV) induces an Fc-binding activity in cells upon infection, but the gene that encodes this Fc-binding protein has not been identified. Here, we demonstrate that the HCMV AD169 open reading frame TRL11 and its identical copy, IRL11, encode a type I membrane glycoprotein that possesses IgG Fc-binding capabilities.

PMID:
11602761
[PubMed - indexed for MEDLINE]
PMCID:
PMC114701
Free PMC Article
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