A hypothesis about tumour development and the clinical features of hereditary breast cancers

Eur J Cancer. 2001 Nov;37(16):2023-9. doi: 10.1016/s0959-8049(01)00228-3.

Abstract

A unifying hypothesis is presented about tumour biology in hereditary breast cancer in relation to the epithelial origin and the degree of differentiation of the normal epithelium at the time of tumour initiation. By using different breast cancer syndromes as examples, it is possible to, at least partly, predict the tumour biology, clinical presentation and therapeutic response.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Ataxia Telangiectasia Mutated Proteins
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / therapy
  • Cell Cycle Proteins
  • Cell Transformation, Neoplastic / genetics*
  • DNA-Binding Proteins
  • Female
  • Genes, BRCA1
  • Genes, BRCA2
  • Genes, p53
  • Humans
  • Middle Aged
  • Mutation
  • Neoplasm Proteins / genetics
  • Neoplastic Syndromes, Hereditary / genetics*
  • Neoplastic Syndromes, Hereditary / therapy
  • Protein Serine-Threonine Kinases / genetics
  • Tumor Suppressor Proteins

Substances

  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Neoplasm Proteins
  • Tumor Suppressor Proteins
  • ATM protein, human
  • Ataxia Telangiectasia Mutated Proteins
  • Protein Serine-Threonine Kinases