Ricin. [Toxicon. 2001] - PubMed Result

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1: Toxicon. 2001 Nov;39(11):1723-8. Links

Ricin.

Olsnes S, Kozlov JV.

Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310, Oslo, Norway. olsnes@radium.uio.no

The plant toxin ricin consists of two disulfide-linked polypeptides with different functions. The A-chain enters the cytosol and inactivates the ribosomes enzymatically, whereas the B-chain has lectin properties and binds to carbohydrates at the cell surface. This binding is a requirement for translocation of the A-chain to the cytosol. The bound toxin is endocytosed and transported retrograde through the Golgi apparatus to the endoplasmic reticulum where it appears to be translocated to the cytosol by the sec61p complex.

PMID: 11595634 [PubMed - indexed for MEDLINE]

ReviewRetrograde transport of ricin.
Int J Med Microbiol. 2002 Feb; 291(6-7):517-21.

[Int J Med Microbiol. 2002]
Dependence of ricin toxicity on translocation of the toxin A-chain from the endoplasmic reticulum to the cytosol.
J Biol Chem. 1999 Nov 26; 274(48):34443-9.

[J Biol Chem. 1999]
ReviewEndocytosis and intracellular transport of ricin: recent discoveries.
FEBS Lett. 1999 Jun 4; 452(1-2):67-70.

[FEBS Lett. 1999]
ReviewRicin transport into cells: studies of endocytosis and intracellular transport.
Int J Med Microbiol. 2000 Oct; 290(4-5):415-20.

[Int J Med Microbiol. 2000]
Retrograde transport of mutant ricin to the endoplasmic reticulum with subsequent translocation to cytosol.
Proc Natl Acad Sci U S A. 1997 Apr 15; 94(8):3783-8.

[Proc Natl Acad Sci U S A. 1997]
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Cited by 10 PubMed Central articles

Intrapulmonary delivery of ricin at high dosage triggers a systemic inflammatory response and glomerular damage.
Wong J, Korcheva V, Jacoby DB, Magun B. Am J Pathol. 2007 May; 170(5):1497-510.

[Am J Pathol. 2007]
Public health investigation after the discovery of ricin in a South Carolina postal facility.
Schier JG, Patel MM, Belson MG, Patel A, Schwartz M, Fitzpatrick N, Drociuk D, Deitchman S, Meyer R, Litovitz T, et al. Am J Public Health. 2007 Apr; 97 Suppl 1:S152-7. Epub 2007 Apr 5.

[Am J Public Health. 2007]
Role of apoptotic signaling pathways in regulation of inflammatory responses to ricin in primary murine macrophages.
Korcheva V, Wong J, Lindauer M, Jacoby DB, Iordanov MS, Magun B. Mol Immunol. 2007 Apr; 44(10):2761-71. Epub 2007 Jan 25.

[Mol Immunol. 2007]
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