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Cell. 2001 Oct 5;107(1):1-3.

HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus.

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  • 1McKusick-Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. gsemenza@jhmi.edu

Abstract

Hypoxia-inducible factor 1 (HIF-1) is a global regulator of cellular and systemic O(2) homeostasis in animals. A molecular basis for O(2)-regulated expression of the HIF-1 alpha subunit has now been determined, providing a mechanism for changes in gene expression in response to changes in cellular oxygenation.

PMID:
11595178
[PubMed - indexed for MEDLINE]
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