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Mol Genet Metab. 2001 Sep-Oct;74(1-2):147-59.

Queuosine modification of tRNA: a case for convergent evolution.

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  • 1The Center for Pediatric Research, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, Virginia 23510, USA. morrisrc@chkd.com


Queuosine is a hypermodified nucleoside found in position 34, the anticodon wobble position, of four tRNA species. This modification is distributed with near uniformity across all life forms found on this planet. Yet the molecular mechanisms involved with accomplishing this ubiquitous posttranscriptional modification of tRNA are dramatically different between prokaryotic and eukaryotic organisms, which suggests that these were formed by convergent evolution of a fundamental life process essential to nearly all life forms. This minireview describes the differences between these modification systems and points to a new direction for developing research on the molecular function queuosine-modified tRNA in diverse species.

Copyright 2001 Academic Press.

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