FEBS Lett. 2001 Sep 28;506(1):6-10.

The polymerization mechanism of the bacterial cell division protein FtsZ.

Source

Department of Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands.

Abstract

Bacteria and archaea usually divide symmetrically by formation of a septum in the middle of the cell. A key event in cell division is the assembly of the FtsZ ring. FtsZ is the prokaryotic homolog of tubulin and forms polymers in the presence of guanine nucleotides. Here, we specifically address the polymerization of FtsZ and the role of nucleotide hydrolysis in polymer formation and stabilization. Recent structural and biochemical results are discussed and a model for FtsZ polymerization, similar to that for tubulin, is presented.

PMID:: 11591361; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

See the articles identified as outstanding by F1000's Faculty of 10,000 renowned researchers and clinicians. - F1000

Supplemental Content

Save items

Related citations in PubMed

Polymerization of Ftsz, a bacterial homolog of tubulin. is assembly cooperative? [J Biol Chem. 2001]
Polymerization of Ftsz, a bacterial homolog of tubulin. is assembly cooperative?
Romberg L, Simon M, Erickson HP. J Biol Chem. 2001 Apr 13; 276(15):11743-53. Epub 2001 Jan 4.
Rate-limiting guanosine 5'-triphosphate hydrolysis during nucleotide turnover by FtsZ, a prokaryotic tubulin homologue involved in bacterial cell division. [Biochemistry. 2004]
Rate-limiting guanosine 5'-triphosphate hydrolysis during nucleotide turnover by FtsZ, a prokaryotic tubulin homologue involved in bacterial cell division.
Romberg L, Mitchison TJ. Biochemistry. 2004 Jan 13; 43(1):282-8.
Immediate GTP hydrolysis upon FtsZ polymerization. [Mol Microbiol. 2002]
Immediate GTP hydrolysis upon FtsZ polymerization.
Scheffers DJ, Driessen AJ. Mol Microbiol. 2002 Mar; 43(6):1517-21.
Review Tubulin and FtsZ structures: functional and therapeutic implications. [Bioessays. 1998]
Review Tubulin and FtsZ structures: functional and therapeutic implications.
Desai A, Mitchison TJ. Bioessays. 1998 Jul; 20(7):523-7.
Review Strong FtsZ is with the force: mechanisms to constrict bacteria. [Trends Microbiol. 2010]
Review Strong FtsZ is with the force: mechanisms to constrict bacteria.
Mingorance J, Rivas G, Vélez M, Gómez-Puertas P, Vicente M. Trends Microbiol. 2010 Aug; 18(8):348-56. Epub 2010 Jul 1.

See reviews... See all...

Cited by 7 PubMed Central articles

The GTPase activity of Escherichia coli FtsZ determines the magnitude of the FtsZ polymer bundling by ZapA in vitro. [Biochemistry. 2009]
The GTPase activity of Escherichia coli FtsZ determines the magnitude of the FtsZ polymer bundling by ZapA in vitro.
Mohammadi T, Ploeger GE, Verheul J, Comvalius AD, Martos A, Alfonso C, van Marle J, Rivas G, den Blaauwen T. Biochemistry. 2009 Nov 24; 48(46):11056-66.
Kinetic modeling of the assembly, dynamic steady state, and contraction of the FtsZ ring in prokaryotic cytokinesis. [PLoS Comput Biol. 2008]
Kinetic modeling of the assembly, dynamic steady state, and contraction of the FtsZ ring in prokaryotic cytokinesis.
Surovtsev IV, Morgan JJ, Lindahl PA. PLoS Comput Biol. 2008 Jul 4; 4(7):e1000102. Epub 2008 Jul 4.
A mechanical explanation for cytoskeletal rings and helices in bacteria. [Biophys J. 2007]
A mechanical explanation for cytoskeletal rings and helices in bacteria.
Andrews SS, Arkin AP. Biophys J. 2007 Sep 15; 93(6):1872-84. Epub 2007 May 18.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The polymerization mechanism of the bacterial cell division protein FtsZ.
The polymerization mechanism of the bacterial cell division protein FtsZ.
FEBS Lett. 2001 Sep 28 ;506(1):6-10.

PubMed
Getting the adrenaline going: crystal structure of the adrenaline-synthesizing e...
Getting the adrenaline going: crystal structure of the adrenaline-synthesizing enzyme PNMT.
Structure. 2001 Oct ;9(10):977-85.

PubMed
Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells.
Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells.
Curr Biol. 2001 Oct 2 ;11(19):1553-8.

PubMed
The changing nature of elective laparoscopic surgery: a review over a 7 year per...
The changing nature of elective laparoscopic surgery: a review over a 7 year period in a reproductive surgery unit.
Hum Fertil (Camb). 2001 ;4(1):31-6.

PubMed
Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice...
Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice.
BMC Neurosci. 2001 ;2:11. Epub 2001 Aug 24 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: