Neuroreport. 2001 Sep 17;12(13):2849-53.

Behavioural and functional anatomical correlates of deception in humans.

Spence SA, Farrow TF, Herford AE, Wilkinson ID, Zheng Y, Woodruff PW.

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SCANLab, Academic Department of Psychiatry, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK.

Abstract

Brain activity in humans telling lies has yet to be elucidated. We developed an objective approach to its investigation, utilizing a computer-based interrogation and fMRI. Interrogatory questions probed recent episodic memory in 30 volunteers studied outside and 10 volunteers studied inside the MR scanner. In a counter-balanced design subjects answered specified questions both truthfully and with lies. Lying was associated with longer response times (p < 0.001) and greater activity in bilateral ventrolateral prefrontal cortices (p < 0.05, corrected). These findings were replicated using an alternative protocol. Ventrolateral prefrontal cortex may be engaged in generating lies or withholding the truth.

PMID:: 11588589; [PubMed - indexed for MEDLINE]

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SumsDB (Surface Management System Database) and WebCaret Online Visualization: SumsDB: Brain-mapping data: deception: lying vs truthful responses: visual task - Neuroscience Information Framework

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Behavioural and functional anatomical correlates of deception in humans.

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