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Measurement of cardiac troponins.
Department of Chemical Pathology, St George's Hospital, London, UK. poctrop@poctrop.demon.co.uk
The cardiac troponins form part of the regulatory mechanism for muscle contraction. Specific cardiac isoforms of cardiac troponin T and cardiac troponin I exist and commercially available immunoassay systems have been developed for their measurement. A large number of clinical and analytical studies have been performed and the measurement of cardiac troponins is now considered the 'gold standard' biochemical test for diagnosis of myocardial damage. There have been advances in understanding the development and structure of troponins and their degradation following myocardial cell necrosis. This has contributed to the understanding of the problems with current assays. Greater clinical use has also highlighted areas of analytical and clinical confusion. The assays are reviewed based on manufacturers' information, current published material as well as the authors' in-house experience.
PMID: 11587122 [PubMed - indexed for MEDLINE]
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Cited by 8 PubMed Central articles
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Two cases of inflammatory muscle disease presenting with raised serum concentrations of troponin T.
Hamilton JS, Sharpe PC.
J Clin Pathol. 2005 Dec; 58(12):1323-4.
[J Clin Pathol. 2005]
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Cardiac troponins in intensive care.
Collinson P, Gaze D.
Crit Care. 2005 Aug; 9(4):345-6. Epub 2005 Jul 20.
[Crit Care. 2005]
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Mitral annular myocardial velocity assessment of segmental left ventricular diastolic function after prolonged exercise in humans.
George K, Oxborough D, Forster J, Whyte G, Shave R, Dawson E, Stephenson C, Dugdill L, Edwards B, Gaze D.
J Physiol. 2005 Nov 15; 569(Pt 1):305-13. Epub 2005 Aug 18.
[J Physiol. 2005]
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