Molecular genetic analysis of diabetes in mice

Trends Genet. 2001 Oct;17(10):S23-8. doi: 10.1016/s0168-9525(01)02453-2.

Abstract

Transgenic and 'knockout' models are increasingly used to study the role of the immune system, insulin signaling and beta-cell gene transcription in diabetes. Mice and humans have similar genetics, developmental biology and physiology. In interpreting these models, however, one needs to be mindful of some differences that exist between mice and humans.

Publication types

  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus, Type 1 / etiology
  • Diabetes Mellitus, Type 1 / genetics*
  • Diabetes Mellitus, Type 2 / etiology
  • Diabetes Mellitus, Type 2 / genetics*
  • Disease Models, Animal
  • Humans
  • Insulin / physiology
  • Islets of Langerhans / physiopathology
  • Mice
  • Mice, Inbred NOD
  • Mice, Knockout
  • Mice, Obese
  • Mice, Transgenic
  • Molecular Biology
  • Species Specificity

Substances

  • Insulin