Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Mol Cell Biol. 2001 Oct;2(10):760-8.

PKB/AKT: functional insights from genetic models.

Author information

  • 1Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9.


Since its discovery 10 years ago, the potential functions of protein kinase B (PKB)/AKT have been catalogued with increasing efficiency. The physiological relevance of some of the proposed mechanisms by which PKB/AKT mediates many of its effects has been questioned, and recent work using new reagents and approaches has revealed some cracks in our understanding of this important molecule, and also hinted that these effects may involve other players.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk