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Nat Rev Mol Cell Biol. 2001 Oct;2(10):731-7.

The INK4a/ARF network in tumour suppression.

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  • 1Department of Tumor Cell Biology, Howard Hughes Medical Institute, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38105, USA.


The retinoblastoma protein (RB) and p53 transcription factor are regulated by two distinct proteins that are encoded by the INK4a/ARF locus. Genes encoding these four tumour suppressors are disabled, either in whole or in part, in most human cancers. A complex signalling network that interconnects the activities of RB and p53 monitors oncogenic stimuli to provide a cell-autonomous mode of tumour surveillance.

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