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Nat Rev Mol Cell Biol. 2001 Oct;2(10):731-7.

The INK4a/ARF network in tumour suppression.

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  • 1Department of Tumor Cell Biology, Howard Hughes Medical Institute, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38105, USA. sherr@stjude.org


The retinoblastoma protein (RB) and p53 transcription factor are regulated by two distinct proteins that are encoded by the INK4a/ARF locus. Genes encoding these four tumour suppressors are disabled, either in whole or in part, in most human cancers. A complex signalling network that interconnects the activities of RB and p53 monitors oncogenic stimuli to provide a cell-autonomous mode of tumour surveillance.

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