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Science. 2001 Sep 28;293(5539):2465-70.

Dendrodendritic inhibition through reversal of dopamine transport.

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  • 1Department of Pharmacology and Experimental Therapeutics, Boston University Medical Center, Boston, MA 02118, USA.

Abstract

Synapses in the central nervous system are usually defined by presynaptic exocytotic release sites and postsynaptic differentiations. We report here a demonstration of dendrodendritic inhibition that does not engage a conventional synapse. Using amperometric and patch-clamp recordings in rat brain slices of the substantia nigra, we found that blockade of the dopamine transporter abolished the dendritic release of dopamine and the resulting self-inhibition. These findings demonstrate that dendrodendritic autoinhibition entails the carrier-mediated release of dopamine rather than conventional exocytosis. This suggests that some widely used antidepressants that inhibit the dopamine transporter may benefit patients in the early stages of Parkinson's disease.

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PMID:
11577238
[PubMed - indexed for MEDLINE]
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