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J Infect Dis. 2001 Oct 15;184(8):1086-90. Epub 2001 Sep 28.

Nitric oxide and cytokine synthesis in human African trypanosomiasis.

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  • 1Department of Zoology, University of Aberdeen, Aberdeen AB24 2TZ, Scotland, United Kingdom.

Abstract

Plasma and cerebrospinal fluid (CSF) concentrations of nitrate and the cytokines interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, interleukin (IL)-10, and IL-4 were measured in 91 African trypanosomiasis patients before and after treatment. Nitrate levels overall were not significantly elevated over those for control persons, but a marginal increase in plasma nitrate was detected in patients reporting illness of <40 days' duration. Plasma IFN-gamma and total TNF-alpha concentrations increased during infection, but free TNF-alpha levels were low in all patients. The most dramatic cytokine response was for IL-10, which was significantly elevated in both plasma and CSF during infection but returned to control levels after treatment. The results indicate that human African trypanosomiasis leads to the development of a strong anti-inflammatory cytokine response.

PMID:
11574928
[PubMed - indexed for MEDLINE]
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