Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Genome Biol. 2001;2(9):REVIEWS1026. Epub 2001 Aug 29.

The trappist's approach to pathfinding: elucidating brain wiring using secretory-trap mutagenesis.

Author information

  • Centre for Developmental Genetics, School of Medicine and Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK. a.j.furley@sheffield.ac.uk

Erratum in

  • Genome Biol 2002;3(3):INTERACTIONS2001.


A key problem in using genetics to dissect the wiring of the mammalian brain lies in discovering which of the billions of neural connections have been disrupted by a particular mutation. A novel gene-trap approach targets the genes involved in brain wiring and labels the axons of neurons expressing those genes, enabling the effects of mutations to be observed directly.

[PubMed - indexed for MEDLINE]
Free PMC Article

Images from this publication.See all images (2)Free text

Figure 1
Figure 2
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Write to the Help Desk