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Genome Biol. 2001;2(9):REVIEWS1026. Epub 2001 Aug 29.

The trappist's approach to pathfinding: elucidating brain wiring using secretory-trap mutagenesis.

Author information

  • Centre for Developmental Genetics, School of Medicine and Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK. a.j.furley@sheffield.ac.uk

Erratum in

  • Genome Biol 2002;3(3):INTERACTIONS2001.

Abstract

A key problem in using genetics to dissect the wiring of the mammalian brain lies in discovering which of the billions of neural connections have been disrupted by a particular mutation. A novel gene-trap approach targets the genes involved in brain wiring and labels the axons of neurons expressing those genes, enabling the effects of mutations to be observed directly.

PMID:
11574063
[PubMed - indexed for MEDLINE]
PMCID:
PMC138964
Free PMC Article

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