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Genome Biol. 2001;2(9):REVIEWS1025. Epub 2001 Aug 29.

New clues to the puzzle of mammalian sex determination.

Author information

  • 1Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia. p.koopman@imb.uq.edu.au

Abstract

WT1 and SOX9 are transcription factors with critical roles in mammalian sex determination and gonadal development. Recent studies in vivo clarify the roles of two alternative splice isoforms of WT1, and demonstrate that SOX9 can induce male sex determination.

PMID:
11574062
[PubMed - indexed for MEDLINE]
PMCID:
PMC138963
Free PMC Article

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