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    Cell. 2001 Sep 21;106(6):771-83.

    An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory.

    Kang H, Sun LD, Atkins CM, Soderling TR, Wilson MA, Tonegawa S.

    Source

    Howard Hughes Medical Institute, New Haven, CT 06511, USA.

    Abstract

    Calcium/calmodulin-dependent protein kinase IV (CaMKIV) has been implicated in the regulation of CRE-dependent transcription. To investigate the role of this kinase in neuronal plasticity and memory, we generated transgenic mice in which the expression of a dominant-negative form of CaMKIV (dnCaMKIV) is restricted to the postnatal forebrain. In these transgenic mice, activity-induced CREB phosphorylation and c-Fos expression were significantly attenuated. Hippocampal late LTP (L-LTP) was also impaired, whereas basic synaptic function and early LTP (E-LTP) were unaffected. These deficits correlated with impairments in long-term memory, specifically in its consolidation/retention phase but not in the acquisition phase. These results indicate that neural activity-dependent CaMKIV signaling in the neuronal nucleus plays an important role in the consolidation/retention of hippocampus-dependent long-term memory.

    PMID:
    11572782
    [PubMed - indexed for MEDLINE]

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