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Exp Clin Endocrinol Diabetes. 2001;109(6):307-19.

Rodent obesity models: an overview.

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  • 1Endocrine Division, Lilly Research Laboratories, Eli Lilly and Company Corporate Center, Indianapolis, Indiana 46285, USA. tschoep@gmx.de

Abstract

Animal obesity models differ widely in type and extent of obesity. They are either based on environmental factors (eg. high fat diet induced obesity), spontaneous mutants (i.e. ob/ob mice), genetically engineered animals (eg. mice with melanocortin receptor subtype-4 gene disruption (knock-out)) or mechanical intervention (eg. chemical lesion of the ventromedial hypothalamus). This article reviews available rodent models to study obesity and attempts to highlight the greatest utility for each model.

PMID:
11571668
[PubMed - indexed for MEDLINE]
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