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Exp Clin Endocrinol Diabetes. 2001;109(6):307-19.

Rodent obesity models: an overview.

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  • 1Endocrine Division, Lilly Research Laboratories, Eli Lilly and Company Corporate Center, Indianapolis, Indiana 46285, USA.


Animal obesity models differ widely in type and extent of obesity. They are either based on environmental factors (eg. high fat diet induced obesity), spontaneous mutants (i.e. ob/ob mice), genetically engineered animals (eg. mice with melanocortin receptor subtype-4 gene disruption (knock-out)) or mechanical intervention (eg. chemical lesion of the ventromedial hypothalamus). This article reviews available rodent models to study obesity and attempts to highlight the greatest utility for each model.

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