Neuroreport. 2001 Oct 8;12(14):3033-7.

Light-emitting diode treatment reverses the effect of TTX on cytochrome oxidase in neurons.

Wong-Riley MT, Bai X, Buchmann E, Whelan HT.

Source

Department of Cell Biology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

Abstract

Light close to and in the near-infrared range has documented benefits for promoting wound healing in human and animals. However, mechanisms of its action on cells are poorly understood. We hypothesized that light treatment with a light-emitting diode array at 670 nm (LED) is therapeutic in stimulating cellular events involving increases in cytochrome oxidase activity. LED was administered to cultured primary neurons whose voltage-dependent sodium channels were blocked by tetrodotoxin. The down-regulation of cytochrome oxidase activity by TTX was reverted to control levels by LED. LED alone also up-regulated enzyme activity. Thus, the results are consistent with our hypothesis that LED has a stimulating effect on cytochrome oxidase in neurons, even when they have been functionally silenced by TTX.

PMID:: 11568632; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

R01 EY05439/EY/NEI NIH HHS/United States

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Photobiomodulation directly benefits primary neurons functionally inactivated by toxins: role of cytochrome c oxidase. [J Biol Chem. 2005]
Photobiomodulation directly benefits primary neurons functionally inactivated by toxins: role of cytochrome c oxidase.
Wong-Riley MT, Liang HL, Eells JT, Chance B, Henry MM, Buchmann E, Kane M, Whelan HT. J Biol Chem. 2005 Feb 11; 280(6):4761-71. Epub 2004 Nov 22.
Near-infrared light via light-emitting diode treatment is therapeutic against rotenone- and 1-methyl-4-phenylpyridinium ion-induced neurotoxicity. [Neuroscience. 2008]
Near-infrared light via light-emitting diode treatment is therapeutic against rotenone- and 1-methyl-4-phenylpyridinium ion-induced neurotoxicity.
Liang HL, Whelan HT, Eells JT, Wong-Riley MT. Neuroscience. 2008 Jun 2; 153(4):963-74. Epub 2008 Mar 26.
Characteristics of cytochrome oxidase activity in visual system neurons in kittens reared in conditions of flashing illumination. [Neurosci Behav Physiol. 2005]
Characteristics of cytochrome oxidase activity in visual system neurons in kittens reared in conditions of flashing illumination.
Merkul'eva NS, Makarov FN. Neurosci Behav Physiol. 2005 Oct; 35(8):805-8.
Review Effect of NASA light-emitting diode irradiation on wound healing. [J Clin Laser Med Surg. 2001]
Review Effect of NASA light-emitting diode irradiation on wound healing.
Whelan HT, Smits RL Jr, Buchman EV, Whelan NT, Turner SG, Margolis DA, Cevenini V, Stinson H, Ignatius R, Martin T, et al. J Clin Laser Med Surg. 2001 Dec; 19(6):305-14.
Review Clinical and experimental applications of NIR-LED photobiomodulation. [Photomed Laser Surg. 2006]
Review Clinical and experimental applications of NIR-LED photobiomodulation.
Desmet KD, Paz DA, Corry JJ, Eells JT, Wong-Riley MT, Henry MM, Buchmann EV, Connelly MP, Dovi JV, Liang HL, et al. Photomed Laser Surg. 2006 Apr; 24(2):121-8.

See reviews... See all...

Cited by 8 PubMed Central articles

Acceleration of the meckel syndrome by near-infrared light therapy. [Nephron Extra. 2011]
Acceleration of the meckel syndrome by near-infrared light therapy.
Lim J, Gattone VH 2nd, Sinders R, Miller CA, Liang Y, Harris P, Watkins JB 3rd, Henshel DS. Nephron Extra. 2011 Jan; 1(1):224-34. Epub 2011 Nov 25.
Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by photobiomodulation induced by 670 nm light. [PLoS One. 2012]
Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by photobiomodulation induced by 670 nm light.
Muili KA, Gopalakrishnan S, Meyer SL, Eells JT, Lyons JA. PLoS One. 2012; 7(1):e30655. Epub 2012 Jan 24.
Review Molecular mechanisms of cell proliferation induced by low power laser irradiation. [J Biomed Sci. 2009]
Review Molecular mechanisms of cell proliferation induced by low power laser irradiation.
Gao X, Xing D. J Biomed Sci. 2009 Jan 12; 16:4. Epub 2009 Jan 12.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Light-emitting diode treatment reverses the effect of TTX on cytochrome oxidase ...
Light-emitting diode treatment reverses the effect of TTX on cytochrome oxidase in neurons.
Neuroreport. 2001 Oct 8 ;12(14):3033-7.

PubMed
Pediatric autoimmune neuropsychiatric disorders and streptococcal infections: ro...
Pediatric autoimmune neuropsychiatric disorders and streptococcal infections: role of otolaryngologist.
Laryngoscope. 2001 Sep ;111(9):1515-9.

PubMed
The posterior fat pad sign and use of comparison radiographs in the diagnosis of...
The posterior fat pad sign and use of comparison radiographs in the diagnosis of occult fractures.
J Bone Joint Surg Am. 2001 Sep ;83-A(9):1435-6.

PubMed
Spectroscopic and functional properties of novel 2[4Fe-4S] cluster-containing fe...
Spectroscopic and functional properties of novel 2[4Fe-4S] cluster-containing ferredoxins from the green sulfur bacterium Chlorobium tepidum.
J Biol Chem. 2001 Nov 23 ;276(47):44027-36. Epub 2001 Sep 21 .

PubMed
Measurement of homocysteine and other aminothiols in plasma: advantages of using...
Measurement of homocysteine and other aminothiols in plasma: advantages of using tris(2-carboxyethyl)phosphine as reductant compared with tri-n-butylphosphine.
Clin Chem. 2001 Oct ;47(10):1821-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Light-emitting diode treatment reverses the effect of TTX on cytochrome oxidase in neurons.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 8 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information