Format

Send to:

Choose Destination
See comment in PubMed Commons below
Br J Haematol. 2001 Sep;114(4):917-9.

Vitamin E correlates inversely with non-transferrin-bound iron in sickle cell disease.

Author information

  • 1Department of Haematology, City Hospital Trust, Dudley Road, Birmingham B18 7QH, UK. Sukhjinder.Marwah@cityhospbham.wmids.nhs.uk

Abstract

Decreased serum vitamin E levels are found in homozygous sickle cell disease (SCD). Excessive transfusions may lead high non-transferrin-bound iron (NTBI). Hypothesizing a relationship between the two, vitamin E (measured using high performance liquid chromatography) was significantly lower in 30 SCD patients than in 30 age-/sex-matched controls (P < 0.001), but NTBI (bleomycin assay) was higher (P < 0.001). Vitamin E was lower in 10 transfused patients than in 20 non-transfused patients (P < 0.001) with a significant inverse correlation between the NTBI and vitamin E (r = -0.58, P < 0.001). NTBI associated with iron overload in SCD may increase the potential for oxidative damage and low vitamin E activity may compound this effect.

PMID:
11564086
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk