Biochem Biophys Res Commun. 2001 Sep 21;287(2):556-61.

Functional cross-talk of HIV-1 Tat with p53 through its C-terminal domain.

Ariumi Y, Kaida A, Hatanaka M, Shimotohno K.

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Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan.

Abstract

Human immunodeficiency virus type 1 (HIV-1) Tat repressed the p53-dependent gene expression through its C-terminal domain of Tat (amino acid residues 73-86) independent of the involvement of NF-kappaB and coactivator CBP/p300. Although Tat did not directly bind to p53, this repression required the N-terminal domain of p53. In contrast, Tat and p53 cooperated in the activation of HIV-1 gene expression. Thus, the cross-talk between Tat and p53 may be linked with cellular transformation by HIV-1 infection or activation of HIV-1 replication.

PMID:: 11554765; [PubMed - indexed for MEDLINE]

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