Mapping protein-protein interactions with combinat...[Curr Opin Biotechnol. 2001]

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1: Curr Opin Biotechnol. 2001 Aug;12(4):340-7. Links

Mapping protein-protein interactions with combinatorial biology methods.

Pelletier J, Sidhu S.

Université de Montréal, Département de Chimie, 2900 Edouard-Montpetit, Montréal, Québec H3C 3J7, Canada. joelle.pelletier@umontreal.ca

Extremely diverse, DNA-encoded libraries of peptides and proteins have been constructed that include a linkage between each polypeptide and the encoding DNA. Library members can be selected by virtue of a particular binding specificity, and their protein sequence can be deduced from the sequence of the cognate DNA. Such combinatorial biology methods have proven invaluable in both identifying natural protein-protein interactions and also in mapping the specificities and energetics of these interactions in fine detail.

PMID: 11551461 [PubMed - indexed for MEDLINE]

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