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    Science. 2001 Sep 7;293(5536):1840-2.

    Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses.

    Source

    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA.

    Abstract

    In 1997, an H5N1 influenza A virus was transmitted from birds to humans in Hong Kong, killing 6 of the 18 people infected. When mice were infected with the human isolates, two virulence groups became apparent. Using reverse genetics, we showed that a mutation at position 627 in the PB2 protein influenced the outcome of infection in mice. Moreover, high cleavability of the hemagglutinin glycoprotein was an essential requirement for lethal infection.

    PMID:
    11546875
    [PubMed - indexed for MEDLINE]

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