Display Settings:

Format

Send to:

Choose Destination
Arch Ophthalmol. 2001 Sep;119(9):1329-32.

Progressive change of optical coherence tomography scans in retinal degeneration slow mice.

Author information

  • 1Department of Ophthalmology, Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-0065, Japan. naoichi@med.nagoya-u.ac.jp

Abstract

OBJECTIVE:

To study whether optical coherence tomography (OCT) scans correlate retinal histologic findings with the progression of retinal degeneration in retinal degeneration slow (rds) mice.

METHODS:

Sensory retinal thickness (SRT) and outer retinal thickness (ORT), representing photoreceptor cell layer, in temporal retina at a distance 1 to 2 disc diameters from the optic disc were measured using scan profile in OCT from 6 healthy mice (16 weeks old) and 2-week-old (n = 6), 6-week-old (n = 4), and 60-week-old (n = 2) rds mice. Histologic sections were obtained from Epon-embedded retinas from the corresponding location.

RESULTS:

Cross-sectional OCT images correlated to the corresponding histologic sections in each mouse. Both SRT and ORT of 2-week-old rds mice (150 +/- 4 microm and 28 +/- 4 microm, respectively) lacking photoreceptor outer segments were already shorter than those of healthy mice (174 +/- 5 microm and 37 +/- 6 microm, respectively) (P<.001). In 6-week-old mice, microscopic findings revealed a decreased number of nuclei in the outer nuclear layer, and SRT and ORT (136 +/- 2 microm and 20 +/- 1 microm, respectively) were shorter than those of 2-week-old rds mice (P<.001). The SRT of 60-week-old rds mice without a photoreceptor layer was remarkably reduced (120 +/- 7 microm), and no ORT could be measured.

CONCLUSION:

Our findings suggest a possible relationship between SRT and ORT, as measured by OCT, and histologic change in retinal degenerative diseases.

CLINICAL RELEVANCE:

The quantitative analysis obtained by OCT scans may have potential to detect progressive change in degenerative retina and may be used in studying human retinal degeneration.

PMID:
11545639
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Write to the Help Desk