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Curr Opin Cell Biol. 2001 Oct;13(5):555-62.

Anoikis mechanisms.

Author information

  • 1The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. sfrisch@burnham-inst.org

Abstract

Anoikis is defined as apoptosis that is induced by inadequate or inappropriate cell-matrix interactions. It is involved in a wide diversity of tissue-homeostatic, developmental and oncogenic processes. The central problem of anoikis is to understand how integrin-mediated cell adhesion signals control the apoptotic machinery. In particular, the initiation of the caspase cascade in anoikis remains to be explained.

PMID:
11544023
[PubMed - indexed for MEDLINE]
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