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    Curr Opin Cell Biol. 2001 Oct;13(5):546-54.

    Integrin tyrosine phosphorylation in platelet signaling.

    Source

    COR Therapeutics, Inc., 256 East Grand Avenue, South San Francisco, California 94080, USA. dphillips@corr.com

    Abstract

    The beta 3 integrin cytoplasmic tyrosine (ICY) motif of alpha IIb beta 3 becomes tyrosine phosphorylated during platelet aggregation, causing Shc and myosin to interact with the beta-integrin cytoplasmic domain. Platelets from mice lacking beta 3 ICY motif tyrosines formed defective aggregates and poorly retracted clots, establishing integrin tyrosine phosphorylation as a key mediator of beta 3-integrin signals.

    PMID:
    11544022
    [PubMed - indexed for MEDLINE]

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