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1: J Org Chem. 1990 Oct 12;55(21):5547-9.Links

Chemical synthesis of oligoribonucleotides containing 2-aminopurine: substrates for the investigation of ribozyme function.

Doudna JA, Szostak JW, Rich A, Usman N.

Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.

The chemical synthesis of a fully protected ribonucleoside phosphoramidite, containing 2-aminopurine as the base component, and its incorporation into short oligoribonucleotides as substrates for an engineered ribozyme from Tetrahymena is described.

PMID: 11540922 [PubMed - indexed for MEDLINE]

Structure of the Tetrahymena ribozyme: base triple sandwich and metal ion at the active site.
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