Genesis. 2001 Aug;30(4):213-9.

Cloning and sequence analysis of a zebrafish cDNA encoding DNA (cytosine-5)-methyltransferase-1.

Mhanni AA, Yoder JA, Dubesky C, McGowan RA.

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Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada.

Abstract

The zebrafish has become a well-established animal model for the analysis of development and of several disease phenotypes. Several of the favorable traits that make it a popular model organism would also be beneficial for the study of normal and abnormal vertebrate development in which DNA methylation may play a role. We report the determination of the full-length cDNA sequence corresponding to the zebrafish DNA (cytosine-5-) methyltransferase gene, Dnmt1. It is 4,907 bases long and has an open reading frame predicted to encode a 1,499 amino acid protein that is similar in size and sequence to a number of other methyltransferases identified in other organisms.

PMID:: 11536427; [PubMed - indexed for MEDLINE]

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Cloning and sequence analysis of a zebrafish cDNA encoding DNA (cytosine-5)-methyltransferase-1.

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