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J Cell Biol. 2001 Sep 3;154(5):909-11.

A new view of the spindle checkpoint.

Author information

  • Department of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA. hoyt@jhu.edu

Abstract

Previous studies of the spindle checkpoint suggested that its ability to prevent entry into anaphase was mediated by the inhibition of the anaphase-promoting complex (APC) ubiquitin ligase by Mad2. Two new studies challenge that view by demonstrating that another checkpoint protein, BubR1, is a far more potent inhibitor of APC function.

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PMID:
11535614
[PubMed - indexed for MEDLINE]
PMCID:
PMC2196198
Free PMC Article
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