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Nat Rev Genet. 2001 Sep;2(9):702-15.

Time zones: a comparative genetics of circadian clocks.

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  • 1Laboratory of Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA.


The circadian clock is a widespread cellular mechanism that underlies diverse rhythmic functions in organisms from bacteria and fungi, to plants and animals. Intense genetic analysis during recent years has uncovered many of the components and molecular mechanisms comprising these clocks. Although autoregulatory genetic networks are a consistent feature in the design of all clocks, the weight of evidence favours their independent evolutionary origins in different kingdoms.

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