Nat Cell Biol. 2001 Sep;3(9):E201-4.

A new view of mRNA export: separating the wheat from the chaff.

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Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA. rreed@hms.harvard.edu

Abstract

Current models for the export of messenger RNA share the notion that the highly abundant class of nuclear RNA-binding proteins--the hnRNP proteins--have a key role in exporting RNA. But recent studies have led to a new understanding of several non-hnRNP proteins, including SR proteins and the conserved mRNA export factor ALY, which are recruited to the mRNA during pre-mRNA splicing. These studies, together with older work on hnRNP particles and assembly of the spliceosome, lead us to a new view of mRNA export. In our model, the non-hnRNP factors form a splicing-dependent mRNP complex that specifically targets mature mRNA for export, while hnRNP proteins retain introns in the nucleus. A machinery that is conserved between yeast and higher eukaryotes functions to export the mRNA.

PMID:: 11533670; [PubMed - indexed for MEDLINE]

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Review A conserved mRNA export machinery coupled to pre-mRNA splicing. [Cell. 2002]
Review A conserved mRNA export machinery coupled to pre-mRNA splicing.
Reed R, Hurt E. Cell. 2002 Feb 22; 108(4):523-31.
The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans. [Nature. 2000]
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Differential binding of heterogeneous nuclear ribonucleoproteins to mRNA precursors prior to spliceosome assembly in vitro. [Mol Cell Biol. 1992]
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Bennett M, Piñol-Roma S, Staknis D, Dreyfuss G, Reed R. Mol Cell Biol. 1992 Jul; 12(7):3165-75.
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A new view of mRNA export: separating the wheat from the chaff.

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