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    J Biol Chem. 2001 Nov 2;276(44):40998-1004. Epub 2001 Aug 31.

    Inositol 1,3,4-trisphosphate 5/6-kinase is a protein kinase that phosphorylates the transcription factors c-Jun and ATF-2.

    Wilson MP, Sun Y, Cao L, Majerus PW.

    Source

    Washington University School of Medicine, Department of Internal Medicine, St. Louis, Missouri 63110, USA. phil@im.wustl.edu

    Abstract

    Phosphorylation of inositol 1,3,4-trisphosphate by inositol 1,3,4-trisphosphate 5/6-kinase is the first committed step in the formation of higher phosphorylated forms of inositol. We have shown that the eight proteins called the COP9 signalosome complex copurify with calf brain 5/6-kinase. Because the complex has been shown to phosphorylate c-Jun in vitro, we tested both the complex and 5/6-kinase and found that both are able to phosphorylate c-Jun and ATF-2 on serine/threonine residues. These findings establish a link between two major signal transduction systems: the inositol phosphates and the stress response system.

    PMID:
    11533064
    [PubMed - indexed for MEDLINE]
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