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Results: 1 to 20 of 22

1.

alpha-Synuclein gene haplotypes are associated with Parkinson's disease.

Farrer M, Maraganore DM, Lockhart P, Singleton A, Lesnick TG, de Andrade M, West A, de Silva R, Hardy J, Hernandez D.

Hum Mol Genet. 2001 Aug 15;10(17):1847-51.

PMID:
11532993
[PubMed - indexed for MEDLINE]
Free Article
2.

Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes.

West AB, Zimprich A, Lockhart PJ, Farrer M, Singleton A, Holtom B, Lincoln S, Hofer A, Hill L, Müller-Myhsok B, Wszolek ZK, Hardy J, Gasser T.

Eur J Hum Genet. 2001 Sep;9(9):659-66.

PMID:
11571553
[PubMed - indexed for MEDLINE]
Free Article
3.

Complex relationship between Parkin mutations and Parkinson disease.

West A, Periquet M, Lincoln S, Lücking CB, Nicholl D, Bonifati V, Rawal N, Gasser T, Lohmann E, Deleuze JF, Maraganore D, Levey A, Wood N, Dürr A, Hardy J, Brice A, Farrer M; French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility on Parkinson's Disease.

Am J Med Genet. 2002 Jul 8;114(5):584-91. Erratum in: Am J Med Genet 2002 Dec 8;114(8):992.

PMID:
12116199
[PubMed - indexed for MEDLINE]
4.

Clinical, 18F-dopa PET, and genetic analysis of an ethnic Chinese kindred with early-onset parkinsonism and parkin gene mutations.

Wu RM, Shan DE, Sun CM, Liu RS, Hwu WL, Tai CH, Hussey J, West A, Gwinn-Hardy K, Hardy J, Chen J, Farrer M, Lincoln S.

Mov Disord. 2002 Jul;17(4):670-5.

PMID:
12210855
[PubMed - indexed for MEDLINE]
5.

Functional association of the parkin gene promoter with idiopathic Parkinson's disease.

West AB, Maraganore D, Crook J, Lesnick T, Lockhart PJ, Wilkes KM, Kapatos G, Hardy JA, Farrer MJ.

Hum Mol Genet. 2002 Oct 15;11(22):2787-92.

PMID:
12374768
[PubMed - indexed for MEDLINE]
Free Article
6.

Identification of a novel gene linked to parkin via a bi-directional promoter.

West AB, Lockhart PJ, O'Farell C, Farrer MJ.

J Mol Biol. 2003 Feb 7;326(1):11-9.

PMID:
12547187
[PubMed - indexed for MEDLINE]
7.

Parkin is not regulated by the unfolded protein response in human neuroblastoma cells.

West AB, Gonzalez-de-Chavez F, Wilkes K, O'Farrell C, Farrer MJ.

Neurosci Lett. 2003 May 1;341(2):139-42.

PMID:
12686385
[PubMed - indexed for MEDLINE]
8.

Parkin-proven disease: common founders but divergent phenotypes.

Lincoln S, Wiley J, Lynch T, Langston JW, Chen R, Lang A, Rogaeva E, Sa DS, Munhoz RP, Harris J, Marder K, Klein C, Bisceglio G, Hussey J, West A, Hulihan M, Hardy J, Farrer M.

Neurology. 2003 May 27;60(10):1605-10.

PMID:
12771249
[PubMed - indexed for MEDLINE]
9.

Genetics of parkin-linked disease.

West AB, Maidment NT.

Hum Genet. 2004 Mar;114(4):327-36. Epub 2004 Jan 15. Review.

PMID:
14727181
[PubMed - indexed for MEDLINE]
10.

N-myc regulates parkin expression.

West AB, Kapatos G, O'Farrell C, Gonzalez-de-Chavez F, Chiu K, Farrer MJ, Maidment NT.

J Biol Chem. 2004 Jul 9;279(28):28896-902. Epub 2004 Apr 12.

PMID:
15078880
[PubMed - indexed for MEDLINE]
Free Article
11.

Molecular pathophysiology of Parkinson's disease.

Moore DJ, West AB, Dawson VL, Dawson TM.

Annu Rev Neurosci. 2005;28:57-87. Review.

PMID:
16022590
[PubMed - indexed for MEDLINE]
12.

To die or grow: Parkinson's disease and cancer.

West AB, Dawson VL, Dawson TM.

Trends Neurosci. 2005 Jul;28(7):348-52. Review.

PMID:
15913799
[PubMed - indexed for MEDLINE]
13.

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity.

West AB, Moore DJ, Biskup S, Bugayenko A, Smith WW, Ross CA, Dawson VL, Dawson TM.

Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16842-7. Epub 2005 Nov 3.

PMID:
16269541
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration.

Smith WW, Pei Z, Jiang H, Moore DJ, Liang Y, West AB, Dawson VL, Dawson TM, Ross CA.

Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18676-81. Epub 2005 Dec 13.

PMID:
16352719
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Localization of LRRK2 to membranous and vesicular structures in mammalian brain.

Biskup S, Moore DJ, Celsi F, Higashi S, West AB, Andrabi SA, Kurkinen K, Yu SW, Savitt JM, Waldvogel HJ, Faull RL, Emson PC, Torp R, Ottersen OP, Dawson TM, Dawson VL.

Ann Neurol. 2006 Nov;60(5):557-69.

PMID:
17120249
[PubMed - indexed for MEDLINE]
16.

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity.

West AB, Moore DJ, Choi C, Andrabi SA, Li X, Dikeman D, Biskup S, Zhang Z, Lim KL, Dawson VL, Dawson TM.

Hum Mol Genet. 2007 Jan 15;16(2):223-32. Epub 2007 Jan 2.

PMID:
17200152
[PubMed - indexed for MEDLINE]
Free Article
17.

Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain.

Higashi S, Biskup S, West AB, Trinkaus D, Dawson VL, Faull RL, Waldvogel HJ, Arai H, Dawson TM, Moore DJ, Emson PC.

Brain Res. 2007 Jun 25;1155:208-19. Epub 2007 Apr 19.

PMID:
17512502
[PubMed - indexed for MEDLINE]
18.

Dynamic and redundant regulation of LRRK2 and LRRK1 expression.

Biskup S, Moore DJ, Rea A, Lorenz-Deperieux B, Coombes CE, Dawson VL, Dawson TM, West AB.

BMC Neurosci. 2007 Nov 28;8:102.

PMID:
18045479
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Parkin mediates the degradation-independent ubiquitination of Hsp70.

Moore DJ, West AB, Dikeman DA, Dawson VL, Dawson TM.

J Neurochem. 2008 Jun;105(5):1806-19. doi: 10.1111/j.1471-4159.2008.05261.x. Epub 2008 Feb 1.

PMID:
18248624
[PubMed - indexed for MEDLINE]
20.

The therapeutic potential of LRRK2 and alpha-synuclein in Parkinson's disease.

Sen S, West AB.

Antioxid Redox Signal. 2009 Sep;11(9):2167-87. doi: 10.1089/ARS.2009.2430.

PMID:
19271991
[PubMed - indexed for MEDLINE]
Free PMC Article

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