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Fertil Steril. 2001 Sep;76(3):469-73.

Forearm bone density in long-term users of oral combined contraceptives and depot medroxyprogesterone acetate.

Author information

  • 1Human Reproduction Unit, Department of Obstetrics and Gynecology, School of Medicine, Universidade Estadual de Campinas, Campinas, Brazil.

Abstract

OBJECTIVE:

To compare the bone mineral density of users of combined oral contraceptives (OC) or depot medroxyprogesterone acetate (depot-MPA) with women who have never used a hormonal contraceptive method.

DESIGN:

Cross-sectional study.

SETTING:

Academic tertiary-care hospital.

PATIENT(S):

A total of 189 women, aged 30 to 34 years old, were allocated to three groups: 63 who had used OC for at least 2 years; 63 who had used depot-MPA for at least 2 years; and 63 control women who had never used hormonal contraceptives.

INTERVENTION(S):

Each woman's bone mineral density (BMD) was evaluated at the distal and ultradistal section of the radius of the nondominant forearm by the use of single x-ray absorptiometry.

MAIN OUTCOME MEASURE(S):

We obtained BMD measurements for each participant.

RESULT(S):

Independent of the period of use and the section of the forearm studied, we found no difference in BMD for OC or depot-MPA users when compared to women who had never used hormonal contraceptive methods. In addition, BMD was similar between OC users and depot-MPA users. The multiple linear regression analysis showed that the variables associated with BMD were weight, number of pregnancies, and the woman's occupation.

CONCLUSION(S):

Women aged 30 to 34 years who have used OC or depot-MPA have similar BMD as control women. These findings suggest that the use of OC or depot-MPA does not affect the BMD of women in this age group.

PMID:
11532466
[PubMed - indexed for MEDLINE]
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